Nature Communications (Jun 2021)

Systematic benchmarking of tools for CpG methylation detection from nanopore sequencing

  • Zaka Wing-Sze Yuen,
  • Akanksha Srivastava,
  • Runa Daniel,
  • Dennis McNevin,
  • Cameron Jack,
  • Eduardo Eyras

DOI
https://doi.org/10.1038/s41467-021-23778-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Several existing algorithms predict the methylation of DNA using Nanopore sequencing signals, but it is unclear how they compare in performance. Here, the authors benchmark the performance of several such tools, and propose METEORE, a consensus tool that improves prediction accuracy.