ACE2 mouse models: a toolbox for cardiovascular and pulmonary research

Hongpeng Jia; Xinping Yue; Eric Lazartigues

doi:10.1038/s41467-020-18880-0

Nature Communications (Oct 2020)

ACE2 mouse models: a toolbox for cardiovascular and pulmonary research

Hongpeng Jia,
Xinping Yue,
Eric Lazartigues

Affiliations

Hongpeng Jia: Division of Pediatric Surgery, Department of Surgery, Johns Hopkins University School of Medicine
Xinping Yue: Department of Physiology, Louisiana State University Health Sciences Center
Eric Lazartigues: Department of Pharmacology & Experimental Therapeutics, Louisiana State University Health Sciences Center

DOI: https://doi.org/10.1038/s41467-020-18880-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Angiotensin-converting enzyme 2 (ACE2) is a cell surface enzyme previously shown to mediate SARS-CoV, and now SARS-CoV-2, entry into host cells. Here the authors review existing mouse ACE2 models expressing humanized, transgenic, knockout, knockin, conditional and reporter alleles to provide a toolbox for COVID-19 research.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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