Journal of Clinical Tuberculosis and Other Mycobacterial Diseases (Dec 2023)
Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali
- Bocar Baya,
- Ibrahim Sanogo,
- Mahamadou Kone,
- Dianguina Soumare,
- Kadidia Ouattara,
- Amadou Somboro,
- Mamadou Wague,
- Nadie Coulibaly,
- Isaac Koloma,
- Mariam Coulibaly,
- Mohamed Nantoume,
- Mamadou Perou,
- Kadidia Kone,
- Djeneba Coulibaly,
- Hawa Boukary Diarra,
- Bourahima Kone,
- Ayouba Diarra,
- Mamadou D. Coulibaly,
- Moumine Sanogo,
- Bassirou Diarra,
- Mahamadou Diakite,
- Chad J. Achenbach,
- Seydou Doumbia,
- William R. Bishai,
- Sabra L. Klein,
- Jane L. Holl,
- Souleymane Diallo,
- Robert L. Murphy,
- Yacouba Toloba,
- Djeneba Dabitao
Affiliations
- Bocar Baya
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa; Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Ibrahim Sanogo
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mahamadou Kone
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Dianguina Soumare
- Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Kadidia Ouattara
- Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Amadou Somboro
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mamadou Wague
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Nadie Coulibaly
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Isaac Koloma
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mariam Coulibaly
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mohamed Nantoume
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mamadou Perou
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Kadidia Kone
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Djeneba Coulibaly
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Hawa Boukary Diarra
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Bourahima Kone
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Ayouba Diarra
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mamadou D. Coulibaly
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Moumine Sanogo
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Bassirou Diarra
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Mahamadou Diakite
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Chad J. Achenbach
- Northwestern University (NU), Division of Infectious Diseases and Havey Institute for Global Health, Feinberg School of Medicine, Chicago, IL, USA
- Seydou Doumbia
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- William R. Bishai
- Johns Hopkins School of Medicine, Department of Infectious Diseases, Center for Tuberculosis Research, Baltimore, MD, USA
- Sabra L. Klein
- Johns Hopkins Bloomberg School of Public Health, W. Harry Feinstone Department of Molecular Microbiology and Immunology, Baltimore, MD, USA
- Jane L. Holl
- University of Chicago, Biological Sciences Division, Chicago, IL, USA
- Souleymane Diallo
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Robert L. Murphy
- Northwestern University (NU), Division of Infectious Diseases and Havey Institute for Global Health, Feinberg School of Medicine, Chicago, IL, USA; University of Chicago, Biological Sciences Division, Chicago, IL, USA
- Yacouba Toloba
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa; Department of Pneumophtisiology, University Teaching Hospital of Point-G, Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa
- Djeneba Dabitao
- University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Mali, West Africa; Corresponding author at: University Clinical Research Center (UCRC), Faculty of Pharmacy and Faculty of Medicine and Odonto-Stomatology, University of Sciences, Techniques, and Technologies of Bamako (USTTB), Bamako, BP 1805, Mali, West Africa.
- Journal volume & issue
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Vol. 33
p. 100389
Abstract
Background: Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood. Objective: To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis. Methods: We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined. Results: A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59). Conclusion: Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.
