Nature Communications (Mar 2017)

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

  • Zuqiang Liu,
  • Roshni Ravindranathan,
  • Pawel Kalinski,
  • Z. Sheng Guo,
  • David L. Bartlett

DOI
https://doi.org/10.1038/ncomms14754
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Anti-PD-L1 therapy often fails in cancers with minimal lymphocytic infiltrates and low PD-L1 expression. Here, the authors show that an oncolytic virus increases PD-L1 expression in cancer models and that the combination with an anti-PD-L1 antibody enhances therapy by increasing the infiltration of activated T cells, and reducing exhausted T cells.