Nature Communications (Apr 2022)
Single cell transcriptomic analysis reveals cellular diversity of murine esophageal epithelium
- Mohammad Faujul Kabir,
- Adam L. Karami,
- Ricardo Cruz-Acuña,
- Alena Klochkova,
- Reshu Saxena,
- Anbin Mu,
- Mary Grace Murray,
- Jasmine Cruz,
- Annie D. Fuller,
- Margarette H. Clevenger,
- Kumaraswamy Naidu Chitrala,
- Yinfei Tan,
- Kelsey Keith,
- Jozef Madzo,
- Hugh Huang,
- Jaroslav Jelinek,
- Tatiana Karakasheva,
- Kathryn E. Hamilton,
- Amanda B. Muir,
- Marie-Pier Tétreault,
- Kelly A. Whelan
Affiliations
- Mohammad Faujul Kabir
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Adam L. Karami
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Ricardo Cruz-Acuña
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Alena Klochkova
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Reshu Saxena
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Anbin Mu
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Mary Grace Murray
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Jasmine Cruz
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Annie D. Fuller
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Margarette H. Clevenger
- Department of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine
- Kumaraswamy Naidu Chitrala
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- Yinfei Tan
- Fox Chase Cancer Center
- Kelsey Keith
- Coriell Institute for Medical Research
- Jozef Madzo
- Coriell Institute for Medical Research
- Hugh Huang
- Coriell Institute for Medical Research
- Jaroslav Jelinek
- Coriell Institute for Medical Research
- Tatiana Karakasheva
- Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
- Kathryn E. Hamilton
- Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
- Amanda B. Muir
- Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia
- Marie-Pier Tétreault
- Department of Medicine, Gastroenterology and Hepatology Division, Northwestern University Feinberg School of Medicine
- Kelly A. Whelan
- Fels Cancer Institute for Personalized Medicine, Temple University Lewis Katz School of Medicine
- DOI
- https://doi.org/10.1038/s41467-022-29747-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The level of cellular diversity in the esophageal epithelium has yet to be classified at the single cell level. Here the authors analyze the transcriptome of 44,679 murine esophageal keratinocytes to identify an unexpected level of cellular heterogeneity.
