Cardiovascular Diabetology (Sep 2024)

Fully automated epicardial adipose tissue volume quantification with deep learning and relationship with CAC score and micro/macrovascular complications in people living with type 2 diabetes: the multicenter EPIDIAB study

  • Bénédicte Gaborit,
  • Jean Baptiste Julla,
  • Joris Fournel,
  • Patricia Ancel,
  • Astrid Soghomonian,
  • Camille Deprade,
  • Adèle Lasbleiz,
  • Marie Houssays,
  • Badih Ghattas,
  • Pierre Gascon,
  • Maud Righini,
  • Frédéric Matonti,
  • Nicolas Venteclef,
  • Louis Potier,
  • Jean François Gautier,
  • Noémie Resseguier,
  • Axel Bartoli,
  • Florian Mourre,
  • Patrice Darmon,
  • Alexis Jacquier,
  • Anne Dutour

DOI
https://doi.org/10.1186/s12933-024-02411-y
Journal volume & issue
Vol. 23, no. 1
pp. 1 – 10

Abstract

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Abstract Background The aim of this study (EPIDIAB) was to assess the relationship between epicardial adipose tissue (EAT) and the micro and macrovascular complications (MVC) of type 2 diabetes (T2D). Methods EPIDIAB is a post hoc analysis from the AngioSafe T2D study, which is a multicentric study aimed at determining the safety of antihyperglycemic drugs on retina and including patients with T2D screened for diabetic retinopathy (DR) (n = 7200) and deeply phenotyped for MVC. Patients included who had undergone cardiac CT for CAC (Coronary Artery Calcium) scoring after inclusion (n = 1253) were tested with a validated deep learning segmentation pipeline for EAT volume quantification. Results Median age of the study population was 61 [54;67], with a majority of men (57%) a median duration of the disease 11 years [5;18] and a mean HbA1c of7.8 ± 1.4%. EAT was significantly associated with all traditional CV risk factors. EAT volume significantly increased with chronic kidney disease (CKD vs no CKD: 87.8 [63.5;118.6] vs 82.7 mL [58.8;110.8], p = 0.008), coronary artery disease (CAD vs no CAD: 112.2 [82.7;133.3] vs 83.8 mL [59.4;112.1], p = 0.0004, peripheral arterial disease (PAD vs no PAD: 107 [76.2;141] vs 84.6 mL[59.2; 114], p = 0.0005 and elevated CAC score (> 100 vs < 100 AU: 96.8 mL [69.1;130] vs 77.9 mL [53.8;107.7], p < 0.0001). By contrast, EAT volume was neither associated with DR, nor with peripheral neuropathy. We further evidenced a subgroup of patients with high EAT volume and a null CAC score. Interestingly, this group were more likely to be composed of young women with a high BMI, a lower duration of T2D, a lower prevalence of microvascular complications, and a higher inflammatory profile. Conclusions Fully-automated EAT volume quantification could provide useful information about the risk of both renal and macrovascular complications in T2D patients.

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