Pharmaceutics (Feb 2021)

The Effect of <i>Myristica fragrans</i> on Texture Properties and Shelf-Life of Innovative Chewable Gel Tablets

  • Inga Matulyte,
  • Akvile Mataraite,
  • Saule Velziene,
  • Jurga Bernatoniene

DOI
https://doi.org/10.3390/pharmaceutics13020238
Journal volume & issue
Vol. 13, no. 2
p. 238

Abstract

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Chewable gel tablets are an underdeveloped subject, even though there are many simple chewable tablets and gummy candies in the food and pharmaceutical industries. Chewable gel tablets are not as sweet, they can have an active substance, pharmacological effect, and a value of nutrition. The aim of this study was to prepare gelatin-based chewable tablets with Myristica fragrans as a preservative and to determine the shelf-life variability depending on storage conditions, and to evaluate texture changes. Firmness and springiness of gel tablets were measured by a texture analyzer and compared between different storage conditions and the shelf-life of tablets was established by mold growing time. Chewable gel tablets were prepared by using silicone form. Mold was most likely to grow on tablets that have been packaged in squeezable bags (after 14 days 60% of all formulations had a mold, p p p < 0.05).

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