Antidiabetic effect of Chloroxylon swietenia bark extracts on streptozotocin induced diabetic rats

Abstract

Diabetes has been increasing at an alarming rate around the world, and experts have relied on remedies from the utilization of ancient drugs that are essentially derived from plants. The present study aimed to evaluate the antidiabetic potential of Chloroxylon swietenia bark extracts on streptozotocin induced diabetic rats. Diabetes was induced in male albino Wistar rats by single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). The diabetic rats were administered orally with C. swietenia bark (CSB) methanolic (CSBMEt) and aqueous (CSBAEt) (250 mg/kg b.w.) extracts and glibenclamide (600 µg/kg b.w.) by intragastric intubation for 45 days. The result showed a heavy loss in weight, increase in blood glucose and glycosylated hemoglobin level, and decline in plasma insulin and total hemoglobin content. Furthermore, glucose-6-phosphatase and fructose-1,6-bis phosphatase were found to be increased whereas hexokinase and glycogen contents were decreased in STZ induced diabetic rats. CSBAEt, CSBMEt and glibenclamide treated diabetic rats showed moderate reduction in blood glucose and glycosylated hemoglobin levels; in addition, plasma insulin and hemoglobin levels were elevated. The altered activities of carbohydrate metabolizing enzymes and liver glycogen were improved remarkably. CSBMEt results were comparable to the standard drug glibenclamide. The present findings support the usage of the plant extracts for the traditional treatment of diabetes.

Keywords

• Chloroxylon swietenia
• Antidiabetic activity
• Carbohydrate metabolizing enzyme
• Liver glycogen