Stem Cell Research (Jan 2019)

Generation of an induced pluripotent stem cell cohort suitable to investigate sporadic Alzheimer's Disease

  • David C. Schöndorf,
  • Myriam Elschami,
  • Maximilian Schieck,
  • Ebru Ercan-Herbst,
  • Christian Weber,
  • Yasmin Riesinger,
  • Sara Kalman,
  • Doris Steinemann,
  • Dagmar E. Ehrnhoefer

Journal volume & issue
Vol. 34

Abstract

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Alzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (Aß) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers.