Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila

Ruohong Wang; Yandong Yin; Jingshu Li; Hongmiao Wang; Wanting Lv; Yang Gao; Tangci Wang; Yedan Zhong; Zhiwei Zhou; Yuping Cai; Xiaoyang Su; Nan Liu; Zheng-Jiang Zhu

doi:10.1038/s41467-022-31268-6

Nature Communications (Jun 2022)

Global stable-isotope tracing metabolomics reveals system-wide metabolic alternations in aging Drosophila

Ruohong Wang,
Yandong Yin,
Jingshu Li,
Hongmiao Wang,
Wanting Lv,
Yang Gao,
Tangci Wang,
Yedan Zhong,
Zhiwei Zhou,
Yuping Cai,
Xiaoyang Su,
Nan Liu,
Zheng-Jiang Zhu

Affiliations

Ruohong Wang: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yandong Yin: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Jingshu Li: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Hongmiao Wang: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Wanting Lv: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yang Gao: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Tangci Wang: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yedan Zhong: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Zhiwei Zhou: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Yuping Cai: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Xiaoyang Su: Metabolomics Shared Resource, Rutgers Cancer Institute of New Jersey, Rutgers University
Nan Liu: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
Zheng-Jiang Zhu: Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-31268-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Stable-isotope tracing allows quantifying metabolic activity by measuring isotopically labeled metabolites, but its metabolome coverage has been limited. Here, the authors develop a global isotope tracing approach with metabolome-wide coverage and use it to characterize metabolic activities in aging Drosophila.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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