Nature Communications (Aug 2021)
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts
- Deukchae Na,
- Jeesoo Chae,
- Sung-Yup Cho,
- Wonyoung Kang,
- Ahra Lee,
- Seoyeon Min,
- Jinjoo Kang,
- Min Jung Kim,
- Jaeyong Choi,
- Woochan Lee,
- Dongjin Shin,
- Ahrum Min,
- Yu-Jin Kim,
- Kyung-Hun Lee,
- Tae-Yong Kim,
- Yun-Suhk Suh,
- Seong-Ho Kong,
- Hyuk-Joon Lee,
- Woo-Ho Kim,
- Hansoo Park,
- Seock-Ah Im,
- Han-Kwang Yang,
- Charles Lee,
- Jong-Il Kim
Affiliations
- Deukchae Na
- Ewha Institute of Convergence Medicine, Ewha Womans University Mokdong Hospital
- Jeesoo Chae
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Sung-Yup Cho
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Wonyoung Kang
- The Jackson Laboratory for Genomic Medicine
- Ahra Lee
- Department of Life Science, Ewha Womans University
- Seoyeon Min
- Department of Life Science, Ewha Womans University
- Jinjoo Kang
- Department of Life Science, Ewha Womans University
- Min Jung Kim
- Medical Research Center, Genomic Medicine Institute (GMI), Seoul National University
- Jaeyong Choi
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Woochan Lee
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Dongjin Shin
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Ahrum Min
- Cancer Research Institute, Seoul National University
- Yu-Jin Kim
- Cancer Research Institute, Seoul National University
- Kyung-Hun Lee
- Cancer Research Institute, Seoul National University
- Tae-Yong Kim
- Cancer Research Institute, Seoul National University
- Yun-Suhk Suh
- Department of Surgery, Seoul National University College of Medicine
- Seong-Ho Kong
- Department of Surgery, Seoul National University College of Medicine
- Hyuk-Joon Lee
- Cancer Research Institute, Seoul National University
- Woo-Ho Kim
- Cancer Research Institute, Seoul National University
- Hansoo Park
- Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST)
- Seock-Ah Im
- Cancer Research Institute, Seoul National University
- Han-Kwang Yang
- Cancer Research Institute, Seoul National University
- Charles Lee
- The Jackson Laboratory for Genomic Medicine
- Jong-Il Kim
- Department of Biomedical Sciences, Seoul National University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25122-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorouracil and oxaliplatin-based chemotherapy through the integrative profiling of patient-derived xenografts
