Nature Communications (Mar 2020)
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
- Shan Zhang,
- Boris Reljić,
- Chao Liang,
- Baptiste Kerouanton,
- Joel Celio Francisco,
- Jih Hou Peh,
- Camille Mary,
- Narendra Suhas Jagannathan,
- Volodimir Olexiouk,
- Claire Tang,
- Gio Fidelito,
- Srikanth Nama,
- Ruey-Kuang Cheng,
- Caroline Lei Wee,
- Loo Chien Wang,
- Paula Duek Roggli,
- Prabha Sampath,
- Lydie Lane,
- Enrico Petretto,
- Radoslaw M. Sobota,
- Suresh Jesuthasan,
- Lisa Tucker-Kellogg,
- Bruno Reversade,
- Gerben Menschaert,
- Lei Sun,
- David A. Stroud,
- Lena Ho
Affiliations
- Shan Zhang
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- Boris Reljić
- Department of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne
- Chao Liang
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- Baptiste Kerouanton
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- Joel Celio Francisco
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Jih Hou Peh
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- Camille Mary
- SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, Faculty of Medicine, Geneva University
- Narendra Suhas Jagannathan
- Centre for Computational Biology, Duke-NUS Graduate Medical School Singapore
- Volodimir Olexiouk
- Biobix, Lab of Bioinformatics and Computational Genomics, Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University
- Claire Tang
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- Gio Fidelito
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- Srikanth Nama
- Institute of Medical Biology, A*STAR
- Ruey-Kuang Cheng
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Caroline Lei Wee
- Institute of Molecular and Cell Biology, A*STAR
- Loo Chien Wang
- Institute of Molecular and Cell Biology, A*STAR
- Paula Duek Roggli
- SIB-Swiss Institute of Bioinformatics
- Prabha Sampath
- Skin Research Institute of Singapore, A*STAR
- Lydie Lane
- SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, Faculty of Medicine, Geneva University
- Enrico Petretto
- Centre for Computational Biology, Duke-NUS Graduate Medical School Singapore
- Radoslaw M. Sobota
- Institute of Molecular and Cell Biology, A*STAR
- Suresh Jesuthasan
- Lee Kong Chian School of Medicine, Nanyang Technological University
- Lisa Tucker-Kellogg
- Cancer and Stem Cell Biology Program, Duke-NUS Medical School
- Bruno Reversade
- Institute of Medical Biology, A*STAR
- Gerben Menschaert
- Biobix, Lab of Bioinformatics and Computational Genomics, Department of Mathematical Modelling, Statistics and Bioinformatics, Ghent University
- Lei Sun
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- David A. Stroud
- Department of Biochemistry and Molecular Biology, The Bio21 Molecular Science & Biotechnology Institute, University of Melbourne
- Lena Ho
- Cardiovascular Metabolic Disorders Program, Duke-NUS Medical School
- DOI
- https://doi.org/10.1038/s41467-020-14999-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Small open reading frame-encoded peptides (SEPs), shorter than 100 amino acids, are involved in many cell biological processes. Here the authors identify 16 nuclear-encoded mitochondrial SEPs, including BRAWNIN, an essential regulator of respiratory chain complex III assembly and ATP production.
