Nature Communications (Mar 2021)
The transcriptional landscape of Shh medulloblastoma
- Patryk Skowron,
- Hamza Farooq,
- Florence M. G. Cavalli,
- A. Sorana Morrissy,
- Michelle Ly,
- Liam D. Hendrikse,
- Evan Y. Wang,
- Haig Djambazian,
- Helen Zhu,
- Karen L. Mungall,
- Quang M. Trinh,
- Tina Zheng,
- Shizhong Dai,
- Ana S. Guerreiro Stucklin,
- Maria C. Vladoiu,
- Vernon Fong,
- Borja L. Holgado,
- Carolina Nor,
- Xiaochong Wu,
- Diala Abd-Rabbo,
- Pierre Bérubé,
- Yu Chang Wang,
- Betty Luu,
- Raul A. Suarez,
- Avesta Rastan,
- Aaron H. Gillmor,
- John J. Y. Lee,
- Xiao Yun Zhang,
- Craig Daniels,
- Peter Dirks,
- David Malkin,
- Eric Bouffet,
- Uri Tabori,
- James Loukides,
- François P. Doz,
- Franck Bourdeaut,
- Olivier O. Delattre,
- Julien Masliah-Planchon,
- Olivier Ayrault,
- Seung-Ki Kim,
- David Meyronet,
- Wieslawa A. Grajkowska,
- Carlos G. Carlotti,
- Carmen de Torres,
- Jaume Mora,
- Charles G. Eberhart,
- Erwin G. Van Meir,
- Toshihiro Kumabe,
- Pim J. French,
- Johan M. Kros,
- Nada Jabado,
- Boleslaw Lach,
- Ian F. Pollack,
- Ronald L. Hamilton,
- Amulya A. Nageswara Rao,
- Caterina Giannini,
- James M. Olson,
- László Bognár,
- Almos Klekner,
- Karel Zitterbart,
- Joanna J. Phillips,
- Reid C. Thompson,
- Michael K. Cooper,
- Joshua B. Rubin,
- Linda M. Liau,
- Miklós Garami,
- Peter Hauser,
- Kay Ka Wai Li,
- Ho-Keung Ng,
- Wai Sang Poon,
- G. Yancey Gillespie,
- Jennifer A. Chan,
- Shin Jung,
- Roger E. McLendon,
- Eric M. Thompson,
- David Zagzag,
- Rajeev Vibhakar,
- Young Shin Ra,
- Maria Luisa Garre,
- Ulrich Schüller,
- Tomoko Shofuda,
- Claudia C. Faria,
- Enrique López-Aguilar,
- Gelareh Zadeh,
- Chi-Chung Hui,
- Vijay Ramaswamy,
- Swneke D. Bailey,
- Steven J. Jones,
- Andrew J. Mungall,
- Richard A. Moore,
- John A. Calarco,
- Lincoln D. Stein,
- Gary D. Bader,
- Jüri Reimand,
- Jiannis Ragoussis,
- William A. Weiss,
- Marco A. Marra,
- Hiromichi Suzuki,
- Michael D. Taylor
Affiliations
- Patryk Skowron
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Hamza Farooq
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Florence M. G. Cavalli
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- A. Sorana Morrissy
- Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary
- Michelle Ly
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Liam D. Hendrikse
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Evan Y. Wang
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Haig Djambazian
- McGill University Genome Centre, McGill University
- Helen Zhu
- Department of Medical Biophysics, University of Toronto
- Karen L. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Quang M. Trinh
- Computational Biology Program, Ontario Institute for Cancer Research
- Tina Zheng
- Department of Neurology, University of California San Francisco
- Shizhong Dai
- Department of Cellular and Molecular Pharmacology, University of California San Francisco
- Ana S. Guerreiro Stucklin
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Maria C. Vladoiu
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Vernon Fong
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Borja L. Holgado
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Carolina Nor
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Xiaochong Wu
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Diala Abd-Rabbo
- Computational Biology Program, Ontario Institute for Cancer Research
- Pierre Bérubé
- McGill University Genome Centre, McGill University
- Yu Chang Wang
- McGill University Genome Centre, McGill University
- Betty Luu
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Raul A. Suarez
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Avesta Rastan
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Aaron H. Gillmor
- Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary
- John J. Y. Lee
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Xiao Yun Zhang
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Craig Daniels
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Peter Dirks
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- David Malkin
- Department of Medical Biophysics, University of Toronto
- Eric Bouffet
- The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- Uri Tabori
- The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- James Loukides
- The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
- François P. Doz
- SIREDO Center (pediatric, adolescent and young adults oncology), Institut Curie, University of Paris
- Franck Bourdeaut
- SIREDO Center (pediatric, adolescent and young adults oncology), Institut Curie, University of Paris
- Olivier O. Delattre
- INSERM U 830, Institut Curie
- Julien Masliah-Planchon
- Unit of Somatic Genetics, Institut Curie
- Olivier Ayrault
- PSL Research University, Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Institut Curie
- Seung-Ki Kim
- Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children’s Hospital
- David Meyronet
- Hospices Civils de Lyon, Institute of Pathology, University Lyon 1, Department of Cancer Cell Plasticity–INSERM U1052 Cancer Research Center of Lyon
- Wieslawa A. Grajkowska
- Department of Pathology, The Children’s Memorial Health Institute
- Carlos G. Carlotti
- Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of Sao Paulo
- Carmen de Torres
- Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat
- Jaume Mora
- Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat
- Charles G. Eberhart
- Departments of Pathology, Ophthalmology and Oncology, John Hopkins University School of Medicine
- Erwin G. Van Meir
- Department of Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University
- Toshihiro Kumabe
- Department of Neurosurgery, Kitasato University School of Medicine
- Pim J. French
- Department of Neurology, Erasmus University Medical Center
- Johan M. Kros
- Department of Pathology, Erasmus University Medical Center
- Nada Jabado
- Division of Experimental Medicine, McGill University
- Boleslaw Lach
- Department of Pathology and Molecular Medicine, Division of Anatomical Pathology, McMaster University
- Ian F. Pollack
- Department of Neurological Surgery, University of Pittsburgh School of Medicine
- Ronald L. Hamilton
- Department of Pathology, University of Pittsburgh School of Medicine
- Amulya A. Nageswara Rao
- Division of Pediatric Hematology/Oncology, Mayo Clinic
- Caterina Giannini
- Department of Laboratory Medicine and Pathology, Mayo Clinic
- James M. Olson
- Clinical Research Division, Fred Hutchinson Cancer Research Center
- László Bognár
- Department of Neurosurgery, University of Debrecen, Medical and Health Science Centre
- Almos Klekner
- Department of Neurosurgery, University of Debrecen, Medical and Health Science Centre
- Karel Zitterbart
- Department of Pediatric Oncology, Masaryk University School of Medicine
- Joanna J. Phillips
- Department of Neurological Surgery, University of California San Francisco
- Reid C. Thompson
- Department of Neurological Surgery, Vanderbilt Medical Center
- Michael K. Cooper
- Department of Neurology, Vanderbilt Medical Center
- Joshua B. Rubin
- Departments of Neuroscience, Washington University School of Medicine in St. Louis
- Linda M. Liau
- Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles
- Miklós Garami
- 2nd Department of Pediatrics, Semmelweis University
- Peter Hauser
- 2nd Department of Pediatrics, Semmelweis University
- Kay Ka Wai Li
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Ho-Keung Ng
- Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong
- Wai Sang Poon
- Department of Surgery, The Chinese University of Hong Kong
- G. Yancey Gillespie
- Department of Neurosurgery, University of Alabama at Birmingham
- Jennifer A. Chan
- Charbonneau Cancer Institute, University of Calgary
- Shin Jung
- Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School
- Roger E. McLendon
- Department of Pathology, Duke University
- Eric M. Thompson
- Department of Neurosurgery, Duke University
- David Zagzag
- Department of Pathology and Neurosurgery, NYU Grossman School of Medicine and NYU Langone Health
- Rajeev Vibhakar
- Department of Pediatrics, University of Colorado Denver
- Young Shin Ra
- Department of Neurosurgery, University of Ulsan, Asan Medical Center
- Maria Luisa Garre
- U.O. Neurochirurgia, Istituto Giannina Gaslini
- Ulrich Schüller
- Institute of Neuropathology, University Medical Center
- Tomoko Shofuda
- Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital
- Claudia C. Faria
- Division of Neurosurgery, Centro Hospitalar Lisboa Norte (CHULN), Hospital de Santa Maria
- Enrique López-Aguilar
- Division of Pediatric Hematology/Oncology, Hospital Pediatría Centro Médico Nacional century XXI
- Gelareh Zadeh
- Division of Neurosurgery, Toronto Western Hospital, University Health Network
- Chi-Chung Hui
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Vijay Ramaswamy
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Swneke D. Bailey
- Department of Surgery, Division of Thoracic and Upper Gastrointestinal Surgery, Faculty of Medicine, McGill University
- Steven J. Jones
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Andrew J. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Richard A. Moore
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- John A. Calarco
- Department of Cell & Systems Biology, University of Toronto
- Lincoln D. Stein
- Department of Molecular Genetics, University of Toronto
- Gary D. Bader
- Department of Molecular Genetics, University of Toronto
- Jüri Reimand
- Department of Medical Biophysics, University of Toronto
- Jiannis Ragoussis
- McGill University Genome Centre, McGill University
- William A. Weiss
- Department of Neurology, University of California San Francisco
- Marco A. Marra
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency
- Hiromichi Suzuki
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- Michael D. Taylor
- Developmental & Stem Cell Biology Program, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-021-21883-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Sonic Hedgehog medulloblastoma (Shh-MB) comprises four subtypes each with distinct clinical traits. Here the authors characterize the genome, transcriptome, and methylome of Shh-MB subtypes, revealing a complex fusion landscape and the molecular convergence of MYCN and cAMP signaling pathways.
