Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Xiongwen Cao; Alexandra Khitun; Yang Luo; Zhenkun Na; Thitima Phoodokmai; Khomkrit Sappakhaw; Elizabeth Olatunji; Chayasith Uttamapinant; Sarah A. Slavoff

doi:10.1038/s41467-020-20841-6

Nature Communications (Jan 2021)

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Xiongwen Cao,
Alexandra Khitun,
Yang Luo,
Zhenkun Na,
Thitima Phoodokmai,
Khomkrit Sappakhaw,
Elizabeth Olatunji,
Chayasith Uttamapinant,
Sarah A. Slavoff

Affiliations

Xiongwen Cao: Department of Chemistry, Yale University
Alexandra Khitun: Department of Chemistry, Yale University
Yang Luo: Department of Chemistry, Yale University
Zhenkun Na: Department of Chemistry, Yale University
Thitima Phoodokmai: School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC)
Khomkrit Sappakhaw: School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC)
Elizabeth Olatunji: Chemical Biology Institute, Yale University
Chayasith Uttamapinant: School of Biomolecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC)
Sarah A. Slavoff: Department of Chemistry, Yale University

DOI: https://doi.org/10.1038/s41467-020-20841-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Many alternative ORFs are co-encoded with characterized proteins, but their function is often not understood. Here, the authors discover that ribosomal protein L36 is co-encoded with alternative protein, which they identify as an upstream regulator of PI3K-AKT-mTOR signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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