Frontiers in Medicine (Jun 2024)
Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis
- Tanja Fererberger,
- Christa Buechler,
- Arne Kandulski,
- Tanja Elger,
- Johanna Loibl,
- Stephan Schmid,
- Stefanie Sommersberger,
- Stefan Gunawan,
- Sebastian Zundler,
- Sebastian Zundler,
- Muriel Huss,
- Dominik Bettenworth,
- Dominik Bettenworth,
- Sally Kempa,
- Simon Weidlich,
- Bandik Föh,
- Bandik Föh,
- Xinyu Huang,
- Marcin Grzegorzek,
- Stefanie Derer-Petersen,
- Ulrich L. Günther,
- Jens U. Marquardt,
- Claudia Kunst,
- Karsten Gülow,
- Martina Müller,
- Christian Sina,
- Christian Sina,
- Christian Sina,
- Franziska Schmelter,
- Hauke C. Tews
Affiliations
- Tanja Fererberger
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Christa Buechler
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Arne Kandulski
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Tanja Elger
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Johanna Loibl
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Stephan Schmid
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Stefanie Sommersberger
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Stefan Gunawan
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Sebastian Zundler
- Department of Medicine 1, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen-Nürnberg, Germany
- Sebastian Zundler
- Deutsches Zentrum Immuntherapie, University Hospital Erlangen, Erlangen, Germany
- Muriel Huss
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Dominik Bettenworth
- Department of Medicine B - Gastroenterology and Hepatology, University Hospital Münster, Münster, Germany
- Dominik Bettenworth
- Practice for Internal Medicine, Münster, Germany
- Sally Kempa
- Department for Plastic, Hand, and Reconstructive Surgery, University Hospital Regensburg, Regensburg, Germany
- Simon Weidlich
- Department of Internal Medicine II, School of Medicine and Health, University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany
- Bandik Föh
- Institute of Nutritional Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Bandik Föh
- Department of Medicine I, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Xinyu Huang
- 0Institute of Medical Informatics, University of Lübeck, Lübeck, Germany
- Marcin Grzegorzek
- 0Institute of Medical Informatics, University of Lübeck, Lübeck, Germany
- Stefanie Derer-Petersen
- Institute of Nutritional Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Ulrich L. Günther
- 1Institute of Chemistry and Metabolomics, University of Lübeck, Lübeck, Germany
- Jens U. Marquardt
- Department of Medicine I, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Claudia Kunst
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Karsten Gülow
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Martina Müller
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- Christian Sina
- Institute of Nutritional Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Christian Sina
- Department of Medicine I, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Christian Sina
- 2Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering (IMTE), Lübeck, Germany
- Franziska Schmelter
- Institute of Nutritional Medicine, University Medical Center Schleswig-Holstein, Lübeck, Germany
- Hauke C. Tews
- Department of Internal Medicine I, Gastroenterology, Hepatology, Endocrinology, Rheumatology, and Infectious diseases, University Hospital Regensburg, Regensburg, Germany
- DOI
- https://doi.org/10.3389/fmed.2024.1334865
- Journal volume & issue
-
Vol. 11
Abstract
IntoductionIdentification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification.MethodsNuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.ResultsIn particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.DiscussionThese results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.
Keywords
