BioMedicine (Mar 2018)

The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM)

  • Yang Jai-Sing,
  • Peng Yan-Ru,
  • Tsai Shih-Chang,
  • Tyan Yeu-Sheng,
  • Lu Chi-Cheng,
  • Chiu Hong-Yi,
  • Chiu Yu-Jen,
  • Kuo Sheng-Chu,
  • Tsai Yuh-Feng,
  • Lin Ping-Chin,
  • Tsai Fuu-Jen

DOI
https://doi.org/10.1051/bmdcn/2018080101
Journal volume & issue
Vol. 8, no. 1
p. 1

Abstract

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Iodinated contrast media (iodinated CM) have increased ability to absorb x-rays and to visualize structures that normally are impossible to observe in a radiological examination. The use of iodinated CM may destory renal function, commonly known as contrast-induced nephropathy (CIN), which can result in acute renal failure (ARF). This review article mainly focuses on the following areas: (1) classifications of iodinated CM: ionic or non-ionic, high-osmolarity contrast media (HOCM), low-osmolarity contrast media (LOCM) and iso-osmolarity contrast media (IOCM); (2) an introduction to the physical and chemical properties of the non-ionic iodinated CM; (3) the management of anaphylactic reaction by iodinated CM; (4) a suggested single injection of adult doses and maximum dose for non-ionic iodinated CM; (5) the molecular mechanism of contrast-induced nephropathy (CIN); (6) In vitro studies on iodinated CM. Based on above information, this review article provide an insight for understanding the drug safety of iodinated CM.

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