Nature Communications (Jan 2017)

Reconstructing metastatic seeding patterns of human cancers

  • Johannes G. Reiter,
  • Alvin P. Makohon-Moore,
  • Jeffrey M. Gerold,
  • Ivana Bozic,
  • Krishnendu Chatterjee,
  • Christine A. Iacobuzio-Donahue,
  • Bert Vogelstein,
  • Martin A. Nowak

DOI
https://doi.org/10.1038/ncomms14114
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Tumours frequently metastasize to multiple anatomical sites and understanding how these different metastases evolve may be important for therapy. Here, the authors develop a method—Treeomics—that can construct phylogenies from multiple metastases from next-generation sequencing data.