Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum

Thomas Hollin; Steven Abel; Alejandra Falla; Charisse Flerida A. Pasaje; Anil Bhatia; Manhoi Hur; Jay S. Kirkwood; Anita Saraf; Jacques Prudhomme; Amancio De Souza; Laurence Florens; Jacquin C. Niles; Karine G. Le Roch

doi:10.1038/s41467-022-28981-7

Nature Communications (Mar 2022)

Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparum

Thomas Hollin,
Steven Abel,
Alejandra Falla,
Charisse Flerida A. Pasaje,
Anil Bhatia,
Manhoi Hur,
Jay S. Kirkwood,
Anita Saraf,
Jacques Prudhomme,
Amancio De Souza,
Laurence Florens,
Jacquin C. Niles,
Karine G. Le Roch

Affiliations

Thomas Hollin: Department of Molecular, Cell and Systems Biology, University of California Riverside
Steven Abel: Department of Molecular, Cell and Systems Biology, University of California Riverside
Alejandra Falla: Department of Biological Engineering, Massachusetts Institute of Technology
Charisse Flerida A. Pasaje: Department of Biological Engineering, Massachusetts Institute of Technology
Anil Bhatia: Metabolomics Core Facility, University of California
Manhoi Hur: Metabolomics Core Facility, University of California
Jay S. Kirkwood: Metabolomics Core Facility, University of California
Anita Saraf: Stowers Institute for Medical Research
Jacques Prudhomme: Department of Molecular, Cell and Systems Biology, University of California Riverside
Amancio De Souza: Metabolomics Core Facility, University of California
Laurence Florens: Stowers Institute for Medical Research
Jacquin C. Niles: Department of Biological Engineering, Massachusetts Institute of Technology
Karine G. Le Roch: Department of Molecular, Cell and Systems Biology, University of California Riverside

DOI: https://doi.org/10.1038/s41467-022-28981-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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The function of RNA-binding domain abundant in Apicomplexans (RAP) protein family members is largely unknown. Here, using high-throughput functional genomics, including metabolomics, Hollin et al. characterize two RAP proteins that are essential for Plasmodium falciparum survival and control mitochondrial rRNAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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