Nature Communications (Aug 2022)

Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8

  • Zelin Duan,
  • Xuezhen Lin,
  • Lixia Wang,
  • Qiuxin Zhen,
  • Yuefeng Jiang,
  • Chuxin Chen,
  • Jing Yang,
  • Chia-Hsueh Lee,
  • Yan Qin,
  • Ying Li,
  • Bo Zhao,
  • Jianchuan Wang,
  • Zhe Zhang

DOI
https://doi.org/10.1038/s41467-022-32655-9
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Microenvironment localization and activation of L-TGF-β1 determine its specific function. Here, the authors elucidated the underlying mechanisms of specific presentation of L-TGF-β1 on the surface of myeloid lineage cells designated by LRRC33, and its activation by integrin αVβ8.