The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma

Abstract

Tissue-resident F4/80hi macrophages can be found both in normal gut as well as in intestinal tumours. Here the authors show that in the colon these macrophages are CCR2-dependent, while in tumours they gain the ability to self-renew, relying on CSF1 and promoting cancer progression.