Педиатрическая фармакология (Jun 2006)

THE ANALYSIS OF THE RESULTS OF ACUTE LYMPHOBLAST LEUKEMIA TREATMENT IN CHILDREN USING A MODIFIED PROTOCOL COALL 92 IN ST. PETERSBURG

  • E.G. Boichenko,
  • M.B. Ivanovskaya,
  • I.A. Garbuzova,
  • M.A. Shul’gina,
  • M.S. Livshits,
  • T.N. Kulakova,
  • T.A. Makarova,
  • M.B. Belogurova,
  • G.G. Radulesku,
  • T.D. Viktorovich,
  • E.D. Chavpetsova,
  • M.M. Sokolova,
  • Yu.S. Ogorodnikova,
  • G.I. Uleiskaya

Journal volume & issue
Vol. 3, no. 3
pp. 21 – 25

Abstract

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The article presents the results of the treatment of children with acute lymphoblast leukemia (all) according to the coall 92 program in St.-Petersburg from 01.01.1999 to 01.01.2005. 160 primary all patients, aged 4 months to 17 years 4 months were included in the study. International criteria were used to diagnose acute lymphoblast leukemia. A 2 years course of treatment in both risk groups included a 5,5–8 months phase of intensive chemotherapy followed by maintenance therapy. 6 years after the protocol introduction in the common group of patients the following survival rate indices were obtained: the 6 years uneventful survival rate was 63 ± 4,6%, the 6 years relapses free survival rate was 69 ± 4,7%, the 6 years general survival rate was 79 ± 3,7%.Key words: acute lymphoblast leukemia, children, intensive chemotherapy.