An Efficient Approach to Phosphorylated Isoindoline Fused with Triazoles via Zn-Catalyzed Cascade Cyclization of 2–Propynol Benzyl Azides and Diarylphosphine Oxides

Abstract

An efficient approach for the synthesis of phosphorylated isoindoline fused with triazoles via Zn(OTf)2-catalyzed cascade cyclization of easily prepared ortho−propynol benzyl azides and diarylphosphine oxides is developed. The transformation occurred smoothly in moderate to excellent yields and tolerated various propargylic alcohol substrates.

Keywords

• zn-catalyzed
• cascade cyclization
• propargylic alcohols
• azides
• phosphorylated isoindolines
• triazoles