Nature Communications (Jul 2019)

Sphingosine-1-phosphate receptor 3 in the medial prefrontal cortex promotes stress resilience by reducing inflammatory processes

  • Brian F. Corbett,
  • Sandra Luz,
  • Jay Arner,
  • Jiah Pearson-Leary,
  • Abhishek Sengupta,
  • Deanne Taylor,
  • Philip Gehrman,
  • Richard Ross,
  • Seema Bhatnagar

DOI
https://doi.org/10.1038/s41467-019-10904-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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S1PR3 is a G protein coupled receptor, that has a role in inflammation. Here the authors show that in the CNS, S1PR3 may contribute to resilience to stressful experiences; resilient rodents show elevated S1pr3, and knockdown results in greater susceptibility to stress.