Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas

Jie Kang; Lei Cao; Taoyang Yuan; Lu Jin; Yanjiao He; Xing Liu; Cuiping Zhang; Nan Chen; Guofo Ma; Ning Qiao; Bochao Zhang; Wentao Wu; Yuanyu Shi; Hua Gao; Chuzhong Li; Yazhuo Zhang; Zhentao Zuo; Songbai Gui

NeuroImage: Clinical (Jan 2022)

Fornix alterations induce the disruption of default mode network in patients with adamantinomatous craniopharyngiomas

Jie Kang,
Lei Cao,
Taoyang Yuan,
Lu Jin,
Yanjiao He,
Xing Liu,
Cuiping Zhang,
Nan Chen,
Guofo Ma,
Ning Qiao,
Bochao Zhang,
Wentao Wu,
Yuanyu Shi,
Hua Gao,
Chuzhong Li,
Yazhuo Zhang,
Zhentao Zuo,
Songbai Gui

Affiliations

Jie Kang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Lei Cao: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Taoyang Yuan: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
Lu Jin: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Yanjiao He: Department of Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Brain Tumor Center, Beijing Institute for Brain Disorders, Beijing Key Brain Tumor Laboratory, Beijing, China
Xing Liu: Department of Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Brain Tumor Center, Beijing Institute for Brain Disorders, Beijing Key Brain Tumor Laboratory, Beijing, China
Cuiping Zhang: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
Nan Chen: Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, 100096 Beijing, China
Guofo Ma: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Ning Qiao: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Bochao Zhang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Wentao Wu: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Yuanyu Shi: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China
Hua Gao: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
Chuzhong Li: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
Yazhuo Zhang: Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
Zhentao Zuo: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China; Hefei Comprehensive National Science Center, Institute of Artificial Intelligence, Hefei, China; Corresponding authors at: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, China (S. Gui). State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, No.15 Datun Road, Chaoyang District, Beijing, China (Z. Zuo).
Songbai Gui: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Corresponding authors at: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No.119 South 4th Ring West Road, Fengtai District, Beijing, China (S. Gui). State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, No.15 Datun Road, Chaoyang District, Beijing, China (Z. Zuo).

Journal volume & issue: Vol. 36
p. 103215

Abstract

Read online

Adamantinomatous craniopharyngioma (ACPs) are rare embryonic tumors and often involve the hypothalamus. The underlying neural substrate of the hypothalamic involvement (HI)-related cognitive decline in patients with ACP is still unclear. We aimed to combine the multi-modal neuroimaging and histological characteristics of the ACP to explore the potential neural substrate of the HI-related cognitive decline. 45 patients with primary ACPs (invasive, 23; noninvasive, 22) and 52 healthy control subjects (HCs) were admitted to the cross-sectional study. No significant difference in cognitive domains was observed between HCs and patients with noninvasive ACPs (NACP). Patients with invasive ACPs (IACP) showed significantly lower working memory performance (WM, p = 0.002) than patients with NACP. The WM decline was correlated with the disruption of the medial temporal lobe (MTL) subsystem in the default mode network (DMN) (r = 0.45, p = 0.004). The increased radial diffusivity of the fornix, indicating demyelinating process, was correlated with the disruption of the MTL subsystem (r = -0.48, p = 0.002). Our study demonstrated that the fornix alterations link DMN disruption to HI-related cognitive decline in patients with ACPs. ACPs that invade the hypothalamus can provide a natural disease model to investigate the potential neural substrate of HI-related cognitive decline.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

About the journal

Abstract

Keywords