Direction-fixed positional nystagmus following head-roll testing: how is it related with a vestibular pathology?

Abstract

Objective: The goal of this study is to analyze the clinical view of patients with direction-fixed positional nystagmus (DFPN) following head-roll maneuver. Methods: Sixty patients with DFPN were reviewed retrospectively. Patients were categorized into 3 groups according to the direction of nystagmus based on rotation side. Associated problems were documented, and cumulative data were compared between groups. One-way analysis of variance (ANOVA test) was used for statistical analysis (P < 0.05). Results: Thirty-three patients (55%) had stronger nystagmus beating towards the direction of head-roll (Group-A). Three patients developed geotropic LC-BPPV. Fourteen patients had inner ear disease. Sixteen patients (27%) had stronger nystagmus beating against the direction of head roll (Group-B). Nine patients had inner ear disease. None of the patients tested with head-shaking had change of direction of nystagmus. Eleven patients (18%) had DFPN with equal velocity during right or left head-roll maneuver (Group-C). Of those, nine patients had inner ear disease. None of the patients had change of direction of nystagmus. Comparison of the incidence of associated problems (migraine, vestibular neuronitis, Meniere’s disease etc.) in each group was not statistically significant (P˃0.05). Conclusion: Patients with DFPN should be followed for a possibility of vestibular pathology since vestibular problem was documented for more than half of the patients in the follow-up. On the other hand, DFPN could be related with a temporary reason (thermal, physical or drug effect etc.) in some patients who do not exhibit any associated disease. Head-shaking testing is recommended to expose the lateral canal BPPV. But the incidence is low.

Keywords

• Positional nystagmus
• Head-roll maneuver
• Vestibular pathology