Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

Christian F. Guerrero-Juarez; Priya H. Dedhia; Suoqin Jin; Rolando Ruiz-Vega; Dennis Ma; Yuchen Liu; Kosuke Yamaga; Olga Shestova; Denise L. Gay; Zaixin Yang; Kai Kessenbrock; Qing Nie; Warren S. Pear; George Cotsarelis; Maksim V. Plikus

doi:10.1038/s41467-018-08247-x

Nature Communications (Feb 2019)

Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds

Christian F. Guerrero-Juarez,
Priya H. Dedhia,
Suoqin Jin,
Rolando Ruiz-Vega,
Dennis Ma,
Yuchen Liu,
Kosuke Yamaga,
Olga Shestova,
Denise L. Gay,
Zaixin Yang,
Kai Kessenbrock,
Qing Nie,
Warren S. Pear,
George Cotsarelis,
Maksim V. Plikus

Affiliations

Christian F. Guerrero-Juarez: Department of Developmental and Cell Biology, University of California, Irvine
Priya H. Dedhia: Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania
Suoqin Jin: Center for Complex Biological Systems, University of California, Irvine
Rolando Ruiz-Vega: Department of Developmental and Cell Biology, University of California, Irvine
Dennis Ma: Department of Biological Chemistry, University of California, Irvine
Yuchen Liu: Department of Developmental and Cell Biology, University of California, Irvine
Kosuke Yamaga: Department of Developmental and Cell Biology, University of California, Irvine
Olga Shestova: Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania
Denise L. Gay: CEA/INSERM Inserm_U967
Zaixin Yang: Department of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania
Kai Kessenbrock: Department of Biological Chemistry, University of California, Irvine
Qing Nie: Department of Developmental and Cell Biology, University of California, Irvine
Warren S. Pear: Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania
George Cotsarelis: Department of Dermatology, Kligman Laboratories, Perelman School of Medicine at the University of Pennsylvania
Maksim V. Plikus: Department of Developmental and Cell Biology, University of California, Irvine

DOI: https://doi.org/10.1038/s41467-018-08247-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

Read online

The diversity of fibroblasts contributing to wound healing is unclear. Here, the authors use single-cell RNA-sequencing to identify heterogeneity among murine fibroblasts in the wound and find that recruited myeloid cells contribute to adipocyte regeneration during healing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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