Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

Ayesha Sen; Sebastian Kallabis; Felix Gaedke; Christian Jüngst; Julia Boix; Julian Nüchel; Kanjanamas Maliphol; Julia Hofmann; Astrid C. Schauss; Marcus Krüger; Rudolf J. Wiesner; David Pla-Martín

doi:10.1038/s41467-022-34205-9

Nature Communications (Nov 2022)

Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA

Ayesha Sen,
Sebastian Kallabis,
Felix Gaedke,
Christian Jüngst,
Julia Boix,
Julian Nüchel,
Kanjanamas Maliphol,
Julia Hofmann,
Astrid C. Schauss,
Marcus Krüger,
Rudolf J. Wiesner,
David Pla-Martín

Affiliations

Ayesha Sen: Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne
Sebastian Kallabis: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne
Felix Gaedke: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne
Christian Jüngst: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne
Julia Boix: Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne
Julian Nüchel: Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne
Kanjanamas Maliphol: Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne
Julia Hofmann: Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne
Astrid C. Schauss: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne
Marcus Krüger: Cologne Excellence Cluster on Cellular Stress Responses in Ageing-associated Diseases (CECAD), University of Cologne
Rudolf J. Wiesner: Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne
David Pla-Martín: Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne

DOI: https://doi.org/10.1038/s41467-022-34205-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

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Mitochondrial quality control mechanisms prevent damage accumulation, including in mitochondrial DNA (mtDNA). Here, Sen et al. show that altered mtDNA elicits local rearrangements in mitochondrial membrane potential and cristae structure, with mtDNA eliminated through VPS35 endosomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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