Frontiers in Medicine (Mar 2022)

Emergence of Lyme Disease on the French Riviera, a Retrospective Survey

  • Jacques Sevestre,
  • Jacques Sevestre,
  • Antoine Benichou,
  • Vanessa Rio,
  • Pascal Delaunay,
  • Géraldine Gonfrier,
  • Cécile Martaresche,
  • Virginie Carlo,
  • Sarah Nakam,
  • Véronique Mondain,
  • Michel Carles,
  • Pierre Yves Jeandel,
  • Jacques Durant

DOI
https://doi.org/10.3389/fmed.2022.737854
Journal volume & issue
Vol. 9

Abstract

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BackgroundThe French Riviera has been declared free of Lyme Borreliosis (LB) for years. Many patients are referred for presumed LB, sometimes with atypical clinical signs and/or doubtful serology, calling the diagnosis into question.MethodsPatients were assessed for LB diagnosis, depending on clinical presentation, laboratory findings, and further examination by other medical professionals.ResultsAmong 255 patients, 45 (18%) were classified as confirmed LB cases [including 28 ongoing LB (10%) and 17 past LB (8%)], and for 210 (82%) a Lyme borreliosis diagnosis was ruled out. Among ongoing LB, 56% had been exposed to or bitten by ticks, exclusively in rural locations of the Alpes-Maritimes. As a result of the diagnostic procedure, 132 (52%) patients had been treated. An alternative diagnosis was established for 134 (52%) patients, covering a wide range of conditions, including mainly psychological (28%) and neurological conditions (25%) or inflammatory and systemic diseases (22%).ConclusionsOur results strongly suggest the endemicity of LB in the Alpes-Maritimes region. Confirmed LB accounted for 18% of patients while 52% were diagnosed with other conditions.

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