Global Medical Genetics (Sep 2023)

Expression of CD44 in Head and Neck Squamous Cell Carcinoma—An <i>In-Silico</i> Study

  • Loganathan Kavitha,
  • Jayaseelan Vijayashree Priyadharsini,
  • Deepthi Kattula,
  • Umadevi Krishna Mohan Rao,
  • Rajabather Balaji Srikanth,
  • Manogaran Kuzhalmozhi,
  • Kannan Ranganathan

DOI
https://doi.org/10.1055/s-0043-1772459
Journal volume & issue
Vol. 10, no. 03
pp. 221 – 228

Abstract

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Introduction CD44, a multistructural and multifunctional transmembrane glycoprotein, is a promising cancer stem cell (CSC) marker that regulates the properties of CSCs, including self-renewal, tumor initiation, and metastasis, and confers resistance to chemotherapy and radiotherapy. The aim of the present study was to evaluate the gene and protein expression of CD44 and explore its prognostic value in head and neck squamous cell carcinoma (HNSCC).

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