Jichu yixue yu linchuang (Jun 2023)

Olfactory disorder in Parkinson's disease

  • REN Peng, CHEN Yali, ZHANG Xianwen

DOI
https://doi.org/10.16352/j.issn.1001-6325.2023.06.0994
Journal volume & issue
Vol. 43, no. 6
pp. 994 – 997

Abstract

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Olfactory dysfunction is the most common early non-motor symptom of Parkinson's disease (PD), which is used as a marker for the diagnosis of PD. The mechanism of olfactory dysfunction is very complex, which is a challenge in the research. The neuromediator such as the accumulation of α-synuclein, dopamine (DA), acetylcholine (ACh), 5-hydroxytryptamine (5-HT) and inflammatory factors are implicated in the olfactory dysfunction in PD. To further study the mechanism of olfactory dysfunction in PD may provide new ideas and therapeutic targets for treatment.

Keywords