Nature Communications (Jan 2018)
MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A
- Lauren J. Howson,
- Giorgio Napolitani,
- Dawn Shepherd,
- Hemza Ghadbane,
- Prathiba Kurupati,
- Lorena Preciado-Llanes,
- Margarida Rei,
- Hazel C. Dobinson,
- Malick M. Gibani,
- Karen Wei Weng Teng,
- Evan W. Newell,
- Natacha Veerapen,
- Gurdyal S. Besra,
- Andrew J. Pollard,
- Vincenzo Cerundolo
Affiliations
- Lauren J. Howson
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Giorgio Napolitani
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Dawn Shepherd
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Hemza Ghadbane
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Prathiba Kurupati
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Lorena Preciado-Llanes
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Margarida Rei
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- Hazel C. Dobinson
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- Malick M. Gibani
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- Karen Wei Weng Teng
- Agency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN)
- Evan W. Newell
- Agency for Science, Technology and Research (A*STAR), Singapore Immunology Network (SIgN)
- Natacha Veerapen
- School of Biosciences, University of Birmingham
- Gurdyal S. Besra
- School of Biosciences, University of Birmingham
- Andrew J. Pollard
- Oxford Vaccine Group, Department of Paediatrics, University of Oxford and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre
- Vincenzo Cerundolo
- Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-017-02540-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Most MAIT cell response to infection studies are of mice. Here the authors characterize MAIT cell population responses to Salmonella Paratyphi A infection of 25 human volunteers using TCR clonotype analysis and mass cytometry of pre-infection matched to post-infection samples.
