Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart

Sophie Payne; Mala Gunadasa-Rohling; Alice Neal; Andia N. Redpath; Jyoti Patel; Kira M. Chouliaras; Indrika Ratnayaka; Nicola Smart; Sarah De Val

doi:10.1038/s41467-019-10710-2

Nature Communications (Jul 2019)

Regulatory pathways governing murine coronary vessel formation are dysregulated in the injured adult heart

Sophie Payne,
Mala Gunadasa-Rohling,
Alice Neal,
Andia N. Redpath,
Jyoti Patel,
Kira M. Chouliaras,
Indrika Ratnayaka,
Nicola Smart,
Sarah De Val

Affiliations

Sophie Payne: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
Mala Gunadasa-Rohling: BHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford
Alice Neal: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
Andia N. Redpath: BHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford
Jyoti Patel: Division of Cardiovascular Medicine, BHF Centre of Research Excellence, University of Oxford, John Radcliffe Hospital
Kira M. Chouliaras: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
Indrika Ratnayaka: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford
Nicola Smart: BHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford
Sarah De Val: Ludwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford

DOI: https://doi.org/10.1038/s41467-019-10710-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 19

Abstract

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How coronary vessels develop and respond to injury is not fully understood. Here, the authors use murine enhancer:reporter models to identify three transcriptional pathways active in different parts of coronary vasculature. These also contribute to neovascularization in the injured neonatal, but not adult, heart.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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