Nature Communications (Aug 2021)

Conversion of dietary inositol into propionate and acetate by commensal Anaerostipes associates with host health

  • Thi Phuong Nam Bui,
  • Louise Mannerås-Holm,
  • Robert Puschmann,
  • Hao Wu,
  • Antonio Dario Troise,
  • Bart Nijsse,
  • Sjef Boeren,
  • Fredrik Bäckhed,
  • Dorothea Fiedler,
  • Willem M. deVos

DOI
https://doi.org/10.1038/s41467-021-25081-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Here, the authors report an anaerobic metabolic pathway from the dominant gut butyrogen Anaerostipes, showing several strains of this genus to be capable of producing propionate from dietary myo-inositol that associates with reduced fasting-glucose levels in mice.