Research progress on subcellular localization and function of long non-coding RNA

Abstract

The subcellular localization of long non-coding RNA(lncRNA) is closely related to its function. When localized in the nucleus, lncRNA can maintain chromatin structure, regulate gene transcription and participate in variable splicing of mRNA. When localized in the cytoplasm, lncRNA can mediate signal transduction, post-transcriptional regulation, translation and post-translational modification. When localized in the organelles, lncRNA can assist in the function of them. The subcellular localization of lncRNA is closely related to its own sequences and binding proteins. In addition, the development of lncRNA therapy will be facilitated by changing lncRNA subcellular localization in use of constructing Snovector, adding cytosolic localization elements, or techniques like APEX2, which indicates the relationship between the subcellular localization of lncRNA and its function.

Keywords

• long non-coding rna|subcellular localization|function of long non-coding rna