Communications Biology (Jan 2021)
SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus
- Mikail Dogan,
- Lina Kozhaya,
- Lindsey Placek,
- Courtney Gunter,
- Mesut Yigit,
- Rachel Hardy,
- Matthew Plassmeyer,
- Paige Coatney,
- Kimberleigh Lillard,
- Zaheer Bukhari,
- Michael Kleinberg,
- Chelsea Hayes,
- Moshe Arditi,
- Ellen Klapper,
- Noah Merin,
- Bruce Tsan-Tang Liang,
- Raavi Gupta,
- Oral Alpan,
- Derya Unutmaz
Affiliations
- Mikail Dogan
- Jackson Laboratory for Genomic Medicine
- Lina Kozhaya
- Jackson Laboratory for Genomic Medicine
- Lindsey Placek
- Jackson Laboratory for Genomic Medicine
- Courtney Gunter
- Jackson Laboratory for Genomic Medicine
- Mesut Yigit
- Jackson Laboratory for Genomic Medicine
- Rachel Hardy
- Jackson Laboratory for Genomic Medicine
- Matthew Plassmeyer
- Amerimmune
- Paige Coatney
- Amerimmune
- Kimberleigh Lillard
- Amerimmune
- Zaheer Bukhari
- SUNY Downstate Medical Center, Department of Pathology
- Michael Kleinberg
- Calhoun Cardiology Center, University of Connecticut School of Medicine
- Chelsea Hayes
- Department of Pathology & Laboratory Medicine and Transfusion Medicine, Cedars-Sinai Medical Center
- Moshe Arditi
- Department of Pediatric, Division of Pediatric Infectious Diseases and Immunology, Biomedical Sciences, Cedars-Sinai Medical Center
- Ellen Klapper
- Department of Pathology & Laboratory Medicine and Transfusion Medicine, Cedars-Sinai Medical Center
- Noah Merin
- Department of Internal Medicine, Division of Hematology Cedars-Sinai Medical Center
- Bruce Tsan-Tang Liang
- Calhoun Cardiology Center, University of Connecticut School of Medicine
- Raavi Gupta
- SUNY Downstate Medical Center, Department of Pathology
- Oral Alpan
- Amerimmune
- Derya Unutmaz
- Jackson Laboratory for Genomic Medicine
- DOI
- https://doi.org/10.1038/s42003-021-01649-6
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Using SARS-CoV-2-specific antibody- and neutralization assays, Dogan et al find that hospitalized individuals show higher IgG antibody responses and higher neutralization titers compared to outpatient or convalescent plasma donors, providing insights into the host humoral response to SARS CoV-2.
