Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth

• Peter C. Ray,
• Margaret Huggett,
• Penelope A. Turner,
• Malcolm Taylor,
• Laura A. T. Cleghorn,
• Julie Early,
• Anuradha Kumar,
• Shilah A. Bonnett,
• Lindsay Flint,
• Douglas Joerss,
• James Johnson,
• Aaron Korkegian,
• Steven Mullen,
• Abraham L. Moure,
• Susan H. Davis,
• Dinakaran Murugesan,
• Michael Mathieson,
• Nicola Caldwell,
• Curtis A. Engelhart,
• Dirk Schnappinger,
• Ola Epemolu,
• Fabio Zuccotto,
• Jennifer Riley,
• Paul Scullion,
• Laste Stojanovski,
• Lisa Massoudi,
• Gregory T. Robertson,
• Anne J. Lenaerts,
• Gail Freiberg,
• Dale J. Kempf,
• Thierry Masquelin,
• Philip A. Hipskind,
• Joshua Odingo,
• Kevin D. Read,
• Simon R. Green,
• Paul G. Wyatt,
• Tanya Parish

Affiliations

Peter C. Ray

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Margaret Huggett

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Penelope A. Turner

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Malcolm Taylor

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Laura A. T. Cleghorn

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Julie Early

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Anuradha Kumar

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Shilah A. Bonnett

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Lindsay Flint

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Douglas Joerss

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

James Johnson

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Aaron Korkegian

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Steven Mullen

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Abraham L. Moure

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Susan H. Davis

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Dinakaran Murugesan

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Michael Mathieson

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Nicola Caldwell

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Curtis A. Engelhart

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States

Dirk Schnappinger

Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States

Ola Epemolu

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Fabio Zuccotto

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Jennifer Riley

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Paul Scullion

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Laste Stojanovski

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Lisa Massoudi

Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, United States

Gregory T. Robertson

Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, United States

Anne J. Lenaerts

Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado, United States

Gail Freiberg

AbbVie, North Chicago, Illinois, United States

Dale J. Kempf

AbbVie, North Chicago, Illinois, United States

Thierry Masquelin

Discovery Chemistry Research, Eli Lilly and Company, Indianapolis, Indiana, United States

Philip A. Hipskind

Lgenia Inc., Fortville, Indiana, United States

Joshua Odingo

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States

Kevin D. Read

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Simon R. Green

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Paul G. Wyatt

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, U.K.

Tanya Parish

TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, United States