The impact of glycemic control on procalcitonin level in patients with type ii diabetes

Abstract

Background: Diabetes mellitus is a chronic condition characterized by hyperglycemia that can lead to serious complications. It results from a defect in insulin secretion, insulin resistance, or both. Type 2 diabetes mellitus (T2DM) is the most common type of diabetes and mainly affects adults. It is associated with insulin resistance and low-grade chronic inflammation in the adipose tissue, muscles, and liver. Measurement of hemoglobin A1c (HbA1c) is one of the most widely used tests to monitor diabetes. The aim of this study was to shed light on the effect of glycemic control of type 2 diabetes on procalcitonin (PT) levels in order to prevent future complications. Materials and Methods: This case-control study included 68 patients with type 2 diabetes mellitus. At Biochemistry Department, College of Medicine, and University of Baghdad and at Al-Sadiq Teaching Hospital in Al-Hilla City, during the period from July 2020 to October 2020. Hemoglobin A1C (HbA1c) was estimated by using an affinity chromatography assay. These patients were divided according to HbA1c level into bad control group (HbA1c > = 7%) which included 36 patients, and good control group (HbA1c 0.05). In addition, there was no significant correlation between PCT and HbA1c among diabetic patients (r = 0.072, P > 0.05). However, there is a significant differences in mean of PCT values between diabetic patients and control group (P < 0.05). Conclusion: There was no effect of glycemic control on PCT level in patients with T2DM. However, the level of PCT was increased in comparison with non-diabetic healthy subjects.

Keywords

• glycemic control
• procalcitonin level
• the impact
• type 2 diabetes mellitus