Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche

Vahid Niazi; Benyamin Parseh; Milad Ahani; Farshid Karami; Samira Gilanchi; Kamran Atarodi; Mina Soufi; Masoud Soleimani; Soudeh Ghafouri-Fard; Mohammad Taheri; Hakimeh Zali

Biomedicine & Pharmacotherapy (Dec 2020)

Communication between stromal and hematopoietic stem cell by exosomes in normal and malignant bone marrow niche

Vahid Niazi,
Benyamin Parseh,
Milad Ahani,
Farshid Karami,
Samira Gilanchi,
Kamran Atarodi,
Mina Soufi,
Masoud Soleimani,
Soudeh Ghafouri-Fard,
Mohammad Taheri,
Hakimeh Zali

Affiliations

Vahid Niazi: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
Benyamin Parseh: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, 14177-55469, Iran
Milad Ahani: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
Farshid Karami: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran
Samira Gilanchi: Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, 19716-53313, Iran
Kamran Atarodi: Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, 14665-1157, Iran
Mina Soufi: Department of Hematology and Cell Therapy, Faculty of Medical Science, Tarbiat Modares University, Tehran, 14117-13116, Iran
Masoud Soleimani: Department of Hematology and Cell Therapy, Faculty of Medical Science, Tarbiat Modares University, Tehran, 14117-13116, Iran
Soudeh Ghafouri-Fard: Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Taheri: Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hakimeh Zali: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 19716-53313, Iran; Corresponding author at: Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 19857-17443, Iran.

Journal volume & issue: Vol. 132
p. 110854

Abstract

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Extracellular vesicles (EVs) have been regarded as important tools for cell-cell communication. They act as carriers for the transfer of various molecules such as genes, proteins and miRNA. EVs shift and transfer their ingredients to target cells in an active form. These particles have prominent roles in modulation of bone marrow (BM) niche; therefore they can regulate proliferation, differentiation, and other properties of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). This review discusses the different roles of EVs on BM niche; HPCs fate regulation and downstream effects of them on HSCs. Moreover, cellular and molecular mechanisms of BM microenvironment cross-talking are explained in healthy and malignant settings.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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