PLoS ONE (Jul 2010)

Genome-wide association study of pancreatic cancer in Japanese population.

  • Siew-Kee Low,
  • Aya Kuchiba,
  • Hitoshi Zembutsu,
  • Akira Saito,
  • Atsushi Takahashi,
  • Michiaki Kubo,
  • Yataro Daigo,
  • Naoyuki Kamatani,
  • Suenori Chiku,
  • Hirohiko Totsuka,
  • Sumiko Ohnami,
  • Hiroshi Hirose,
  • Kazuaki Shimada,
  • Takuji Okusaka,
  • Teruhiko Yoshida,
  • Yusuke Nakamura,
  • Hiromi Sakamoto

DOI
https://doi.org/10.1371/journal.pone.0011824
Journal volume & issue
Vol. 5, no. 7
p. e11824

Abstract

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Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5x10(-7)) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17-1.43, 1.19-1.47, and 2.24-6.21; P-value of 3.30x10(-7), 3.30x10(-7), and 4.41x10(-7); located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.