Synthesis of the 4’-desmethoxy analogue of RU79115

Abstract

The synthesis, and biological activity in vitro of the 4’-desmethoxy analogue (3) of RU 79115 (2) is described. Comparison of the biological activity of the two analogues clearly indicated the importance of the 4’-methoxy group in conferring good gyrase B inhibitory activity as well as antibacterial activity.

Keywords

• structure-activity
• inhibitor
• gyrase B
• antibacterial
• sugar
• L-arabinose
• coumarin