Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

Brianna J. Klein; Kendra R. Vann; Forest H. Andrews; Wesley W. Wang; Jibo Zhang; Yi Zhang; Anastasia A. Beloglazkina; Wenyi Mi; Yuanyuan Li; Haitao Li; Xiaobing Shi; Andrei G. Kutateladze; Brian D. Strahl; Wenshe R. Liu; Tatiana G. Kutateladze

doi:10.1038/s41467-018-07072-6

Nature Communications (Nov 2018)

Structural insights into the π-π-π stacking mechanism and DNA-binding activity of the YEATS domain

Brianna J. Klein,
Kendra R. Vann,
Forest H. Andrews,
Wesley W. Wang,
Jibo Zhang,
Yi Zhang,
Anastasia A. Beloglazkina,
Wenyi Mi,
Yuanyuan Li,
Haitao Li,
Xiaobing Shi,
Andrei G. Kutateladze,
Brian D. Strahl,
Wenshe R. Liu,
Tatiana G. Kutateladze

Affiliations

Brianna J. Klein: Department of Pharmacology, University of Colorado School of Medicine
Kendra R. Vann: Department of Pharmacology, University of Colorado School of Medicine
Forest H. Andrews: Department of Pharmacology, University of Colorado School of Medicine
Wesley W. Wang: Department of Chemistry, Texas A&M University
Jibo Zhang: Department of Biochemistry & Biophysics, The University of North Carolina School of Medicine
Yi Zhang: Department of Pharmacology, University of Colorado School of Medicine
Anastasia A. Beloglazkina: Department of Chemistry and Biochemistry, University of Denver
Wenyi Mi: Center for Epigenetics, Van Andel Research Institute
Yuanyuan Li: Department of Basic Medical Sciences, School of Medicine, Tsinghua University
Haitao Li: Department of Basic Medical Sciences, School of Medicine, Tsinghua University
Xiaobing Shi: Center for Epigenetics, Van Andel Research Institute
Andrei G. Kutateladze: Department of Chemistry and Biochemistry, University of Denver
Brian D. Strahl: Department of Biochemistry & Biophysics, The University of North Carolina School of Medicine
Wenshe R. Liu: Department of Chemistry, Texas A&M University
Tatiana G. Kutateladze: Department of Pharmacology, University of Colorado School of Medicine

DOI: https://doi.org/10.1038/s41467-018-07072-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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YEATS domains are histone acylation readers that recognize crotonyllysine and acetyllysine. Here the authors provide structural insights into how YEATS domains recognize acetyllysines and further show that the human AF9 YEATS domain also binds DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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