Nature Communications (May 2017)
Mutant KRAS promotes malignant pleural effusion formation
- Theodora Agalioti,
- Anastasios D. Giannou,
- Anthi C. Krontira,
- Nikolaos I. Kanellakis,
- Danai Kati,
- Malamati Vreka,
- Mario Pepe,
- Magda Spella,
- Ioannis Lilis,
- Dimitra E. Zazara,
- Eirini Nikolouli,
- Nikolitsa Spiropoulou,
- Andreas Papadakis,
- Konstantina Papadia,
- Apostolos Voulgaridis,
- Vaggelis Harokopos,
- Panagiota Stamou,
- Silke Meiners,
- Oliver Eickelberg,
- Linda A. Snyder,
- Sophia G. Antimisiaris,
- Dimitrios Kardamakis,
- Ioannis Psallidas,
- Antonia Marazioti,
- Georgios T. Stathopoulos
Affiliations
- Theodora Agalioti
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Anastasios D. Giannou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Anthi C. Krontira
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Nikolaos I. Kanellakis
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Danai Kati
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Malamati Vreka
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Mario Pepe
- Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Magda Spella
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Ioannis Lilis
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Dimitra E. Zazara
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Eirini Nikolouli
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Nikolitsa Spiropoulou
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Andreas Papadakis
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Konstantina Papadia
- Department of Pharmacy, Laboratory for Pharmaceutical Technology, School of Health Sciences, University of Patras, and Foundation for Research and Technology Hellas, Institute of Chemical Engineering, FORTH/ICE-HT
- Apostolos Voulgaridis
- Department of Pulmonary Medicine, Rio University Hospital, Faculty of Medicine, University of Patras
- Vaggelis Harokopos
- Genomics Facility, Biomedical Sciences Research Center ‘Alexander Fleming’
- Panagiota Stamou
- Department of Hematology, Faculty of Medicine, University of Patras
- Silke Meiners
- Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Oliver Eickelberg
- Comprehensive Pneumology Center (CPC) and Institute for Lung Biology and Disease (iLBD), University Hospital, Ludwig-Maximilians University and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL)
- Linda A. Snyder
- Oncology Discovery Research, Janssen R&D LLC
- Sophia G. Antimisiaris
- Department of Pharmacy, Laboratory for Pharmaceutical Technology, School of Health Sciences, University of Patras, and Foundation for Research and Technology Hellas, Institute of Chemical Engineering, FORTH/ICE-HT
- Dimitrios Kardamakis
- Department of Radiation Oncology and Stereotactic Radiotherapy, Faculty of Medicine, University of Patras
- Ioannis Psallidas
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Antonia Marazioti
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- Georgios T. Stathopoulos
- Department of Physiology, Laboratory for Molecular Respiratory Carcinogenesis, Faculty of Medicine, University of Patras
- DOI
- https://doi.org/10.1038/ncomms15205
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Malignant pleural effusion (MPE) is a lethal condition associated with various cancers. Here, the authors show that cancer cells withKRASmutations promote MPE by recruiting myeloid cells via CCL2 signalling and that pharmaceutical targeting of KRAS results in reduced MPE incidence and volume in mouse models.
