Frontiers in Cardiovascular Medicine (Jul 2022)

Prognostic value of N-terminal Pro–B-Type natriuretic peptide in patients with intermediate coronary lesions

  • Chenxi Song,
  • Chenxi Song,
  • Sheng Yuan,
  • Sheng Yuan,
  • Kongyong Cui,
  • Kongyong Cui,
  • Zhongxing Cai,
  • Zhongxing Cai,
  • Rui Zhang,
  • Rui Zhang,
  • Jining He,
  • Jining He,
  • Zheng Qiao,
  • Zheng Qiao,
  • Xiaohui Bian,
  • Xiaohui Bian,
  • Shaoyu Wu,
  • Shaoyu Wu,
  • Haoyu Wang,
  • Haoyu Wang,
  • Rui Fu,
  • Rui Fu,
  • Chunyue Wang,
  • Chunyue Wang,
  • Qianqian Liu,
  • Qianqian Liu,
  • Dong Yin,
  • Dong Yin,
  • Lei Jia,
  • Lei Jia,
  • Kefei Dou,
  • Kefei Dou

DOI
https://doi.org/10.3389/fcvm.2022.903757
Journal volume & issue
Vol. 9

Abstract

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BackgroundThe optimal treatment strategy for patients with coronary intermediate lesions, defined as diameter stenosis of 50–70%, remains a great challenge for cardiologists. Identification of potential biomarkers predictive of major adverse cardiovascular events (MACEs) risk may assist in risk stratification and clinical decision.MethodsA total of 1,187 patients with intermediate coronary lesions and available N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were enrolled in the current study. A baseline NT-proBNP level was obtained. The primary endpoint was defined as MACEs, the composite endpoint of all-cause death and non-fatal myocardial infarction. A multivariate Cox regression model was used to explore the association between NT-proBNP level and MACE risk.ResultsThe mean age of the study cohort was 59.2 years. A total of 68 patients experienced MACE during a median follow-up of 6.1 years. Restricted cubic spline analysis delineated a linear relationship between the baseline NT-proBNP level and MACE risk. Both univariate and multivariate analyses demonstrated that an increased NT-proBNP level was associated with an increased risk of MACE [adjusted hazard ratio (HR) per doubling: 1.412, 95% confidence interval (CI): 1.022–1.952, p = 0.0365]. This association remains consistent in clinical meaningful subgroups according to age, sex, body mass index (BMI), and diabetes.ConclusionAn increased NT-proBNP level is associated with an increased risk of MACE in patients with intermediate coronary lesions and may serve as the potential biomarker for risk stratification and treatment decision guidance.

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