ChemElectroChem (Feb 2021)

Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O2 Control and the Natural Electron Donor

  • Dr. Célia M. Silveira,
  • Dr. Patrícia R. Rodrigues,
  • Dr. Wissam Ghach,
  • Dr. Sofia A. Pereira,
  • Dr. Francisco Esteves,
  • Dr. Michel Kranendonk,
  • Dr. Mathieu Etienne,
  • Prof. Dr. M. Gabriela Almeida

DOI
https://doi.org/10.1002/celc.202001615
Journal volume & issue
Vol. 8, no. 3
pp. 430 – 430

Abstract

Read online

Abstract Invited for this month's cover picture is the Group of Biomarkers and Biosensors – GB2 (https://gb29.webnode.pt) at Universidade NOVA de Lisboa (Portugal) and CiiEM (Portugal). The cover picture shows the electrochemical response of the human monooxygenase enzyme, cytochrome P450 1A2 (CYP1A2), in the presence of its natural electron donor partner, cytochrome P450 oxidoreductase (CPR), highlighting the role of the interaction with the latter in the stabilization of CYP1A2 and attaining the electrochemically driven activity towards O2. The picture also emphasizes the protein entrapment matrix, a biocompatible sol‐gel film, which proved to be crucial for the achievement of interfacial electron transfer. Read the full text of the Article at 10.1002/celc.202001255.