Maternal deaths following nevirapine-based antiretroviral therapy

E Bera; D Naidoo; M Williams

doi:10.4102/sajhivmed.v13i4.116

Southern African Journal of HIV Medicine (Oct 2012)

Maternal deaths following nevirapine-based antiretroviral therapy

E Bera,
D Naidoo,
M Williams

Affiliations

E Bera: Department of Obstetrics and Gynaecology, University of the Witwatersrand and Rahima Moosa Mother-and-Child Hospital, Johannesburg
D Naidoo: Department of Obstetrics and Gynaecology, University of the Witwatersrand and Rahima Moosa Mother-and-Child Hospital, Johannesburg
M Williams: Department of Obstetrics and Gynaecology, University of the Witwatersrand and Rahima Moosa Mother-and-Child Hospital, Johannesburg

DOI: https://doi.org/10.4102/sajhivmed.v13i4.116
Journal volume & issue: Vol. 13, no. 4

Abstract

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We report 2 cases illustrating that it is too simplistic to link nevirapine (NVP) toxicity exclusively to individuals with immune preservation. Not enough is known about the mechanism of hepatotoxicity or cutaneous eruption to predict these events. This type of hypersensitivity reaction occurs rarely among HIV-exposed infants taking NVP prophylaxis or antiretroviral therapy (ART)-experienced adults with complete plasma viral load suppression. Conversely, HIV-uninfected adults and ART-naive pregnant women appear to be disproportionately affected by the adverse effects of NVP.

Published in Southern African Journal of HIV Medicine

ISSN: 1608-9693 (Print); 2078-6751 (Online)
Publisher: AOSIS
Country of publisher: South Africa
LCC subjects: Medicine: Public aspects of medicine; Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://sajhivmed.org.za/index.php/hivmed

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