Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration

Yonghao Wu; Quanle Cao; Yilei Wang; Yunyi Liu; Xiujuan Xu; Puxin Liu; Xiangfeng Li; Xiangdong Zhu; Xingdong Zhang

Materials & Design (Sep 2023)

Optimized fabrication of DLP-based 3D printing calcium phosphate ceramics with high-precision and low-defect to induce calvarial defect regeneration

Yonghao Wu,
Quanle Cao,
Yilei Wang,
Yunyi Liu,
Xiujuan Xu,
Puxin Liu,
Xiangfeng Li,
Xiangdong Zhu,
Xingdong Zhang

Affiliations

Yonghao Wu: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China
Quanle Cao: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China
Yilei Wang: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China
Yunyi Liu: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China
Xiujuan Xu: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China
Puxin Liu: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China
Xiangfeng Li: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China; Corresponding authors at: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Xiangdong Zhu: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China; Corresponding authors at: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Xingdong Zhang: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China; College of Biomedical Engineering, Sichuan University, Chengdu 610064, China; Provincial Engineering Research Center for Biomaterials Genome of Sichuan, Sichuan University, Chengdu 610064, China; NMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterials & Institute of Regulatory Science for Medical Devices & NMPA Research Base of Regulatory Science for Medical Devices, Sichuan University, Chengdu 610064, China

Journal volume & issue: Vol. 233
p. 112230

Abstract

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Acquiring high-performance calcium phosphate (CaP) ceramics via 3D printing is critical for their applications in bone regenerative repair. In current study, a complete process study of 3D printed CaP ceramics based on digital light processing (DLP) technology was performed to get the ideal implant for the regenerative repair of calvarial defects. The smaller particle size of initial powder would be more favorable to getting slurry with high solid content and low viscosity. CaP green body with high precision and high curing rate could be fabricated at the exposure energy density and exposure time of 6.20 mJ cm−2 and 2 s, respectively. Moreover, the post-curing treatment could eliminate the interlayer cracks and increase the curing rate from 69.78% to 93.91% of green body. After that, the mechanical strength of CaP ceramics increased by 46.34%. In-vitro cellular experiments showed that 3D printed CaP ceramics had good biocompatibility, and could promote the osteoblastic differentiation of BMSCs. In-vivo rat cranial defect implantation revealed 3D printed CaP ceramics exhibited better osteogenic ability than the commercial ones (BAM®), reaching the close level with the autografts. Overall, this study could provide a closed-loop solution for 3D printed CaP ceramics with high-precision and low-defect to induce bone regeneration.

Published in Materials & Design

ISSN: 0264-1275 (Print); 1873-4197 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials
Website: https://www.journals.elsevier.com/materials-and-design

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