Nature Communications (Jan 2020)

Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition

  • Morgan Oatley,
  • Özge Vargel Bölükbası,
  • Valentine Svensson,
  • Maya Shvartsman,
  • Kerstin Ganter,
  • Katharina Zirngibl,
  • Polina V. Pavlovich,
  • Vladislava Milchevskaya,
  • Vladimira Foteva,
  • Kedar N. Natarajan,
  • Bianka Baying,
  • Vladimir Benes,
  • Kiran R. Patil,
  • Sarah A. Teichmann,
  • Christophe Lancrin

DOI
https://doi.org/10.1038/s41467-019-14171-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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The endothelial to haematopoietic transition (EHT) is the process where haemogenic endothelium differentiates into haematopoietic stem and progenitor cells (HSPCs). Here the authors use single cell transcriptomics and antibody screening to identify CD44 as a marker of EHT that is required for EHT and HSPC development.