Sex-specific associations between diabetes and dementia: the role of age at onset of disease, insulin use and complications

Abstract

Highlights We evaluated the sex-specific association of T2DM with dementia subtypes, and to examine the roles of age at onset of disease, insulin use and diabetes’ complications in their association. Women with T2DM were 1.56 times more likely to experience AD than men. Early onset T2DM (younger than age 55 years) might be related to higher risk of VD than later onset T2DM (later than age 55 years). Insulin use was linked to 1.5- and 1.9-times higher risk of all-cause dementia and VD, respectively. Different types and numbers of complications modulate the risk of dementia in patients with T2DM.

Keywords

• Type 2 diabetes
• Dementia
• Sex
• Age at onset of diabetes
• Insulin use
• Complications