Frontiers in Medicine (Sep 2021)

Plasma Macrophage Migration Inhibitory Factor Predicts Graft Function Following Kidney Transplantation: A Prospective Cohort Study

  • Yongrong Ye,
  • Fei Han,
  • Maolin Ma,
  • Qipeng Sun,
  • Zhengyu Huang,
  • Haofeng Zheng,
  • Haofeng Zheng,
  • Zhe Yang,
  • Zihuan Luo,
  • Zihuan Luo,
  • Tao Liao,
  • Tao Liao,
  • Heng Li,
  • Liangqing Hong,
  • Ning Na,
  • Qiquan Sun,
  • Qiquan Sun

DOI
https://doi.org/10.3389/fmed.2021.708316
Journal volume & issue
Vol. 8

Abstract

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Background: Delayed graft function (DGF) is a common complication after kidney transplantation (KT) with a poor clinical outcome. There are no accurate biomarkers for the early prediction of DGF. Macrophage migration inhibitory factor (MIF) release during surgery plays a key role in protecting the kidney, and may be a potential biomarker for predicting post-transplant renal allograft recovery.Methods: Recipients who underwent KT between July 2020 and December 2020 were enrolled in the study. Plasma MIF levels were tested in recipients at different time points, and the correlation between plasma MIF and DGF in recipients was evaluated. This study was registered in the Chinese Clinical Trial Registry (ChiCTR2000035596).Results: Intraoperative MIF levels were different between immediate, slowed, and delayed graft function groups (7.26 vs. 6.49 and 5.59, P < 0.001). Plasma MIF was an independent protective factor of DGF (odds ratio = 0.447, 95% confidence interval [CI] 0.264–0.754, P = 0.003). Combining plasma MIF level and donor terminal serum creatinine provided the best predictive power for DGF (0.872; 95%CI 0.795–0.949). Furthermore, plasma MIF was significantly associated with allograft function at 1-month post-transplant (R2 = 0.42, P < 0.001).Conclusion: Intraoperative MIF, as an independent protective factor for DGF, has excellent diagnostic performance for predicting DGF and is worthy of further exploration.

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