In situ click chemistry generation of cyclooxygenase-2 inhibitors

Atul Bhardwaj; Jatinder Kaur; Melinda Wuest; Frank Wuest

doi:10.1038/s41467-016-0009-6

Nature Communications (Feb 2017)

In situ click chemistry generation of cyclooxygenase-2 inhibitors

Atul Bhardwaj,
Jatinder Kaur,
Melinda Wuest,
Frank Wuest

Affiliations

Atul Bhardwaj: Department of Oncology, University of Alberta
Jatinder Kaur: Department of Oncology, University of Alberta
Melinda Wuest: Department of Oncology, University of Alberta
Frank Wuest: Department of Oncology, University of Alberta

DOI: https://doi.org/10.1038/s41467-016-0009-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Traditional inflammation and pain relief drugs target both cyclooxygenase 1 and 2 (COX-1 and COX-2), causing severe side effects. Here, the authors use in situ click chemistry to develop COX-2 specific inhibitors with high in vivo anti-inflammatory activity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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